Nonalcoholic fatty liver disease (
NAFLD) has emerged as a prominent global health concern, representing a substantial burden within the spectrum of chronic
liver diseases. Despite its escalating prevalence, a definitive therapeutic strategy or efficacious pharmacological intervention for
NAFLD has yet to receive official approval to date. While Fu Fang Qiyin granules have exhibited efficacy in addressing
NAFLD, the intricacies of their underlying mechanism of action remain inadequately elucidated. In this study, we substantiated the ameliorative impact of Qiyin on highfat diet (HFD)induced
NAFLD in rat models. The results of metabonomics showed that 108 potential
biomarkers in serum and urine related to
amino acid metabolism, energy metabolism, and
pyrimidine metabolism, have returned to normal levels compared to the model group. Hepatic transcriptomics further indicated that Qiyin potentially confers protective effects against
NAFLD by mediating liver
inflammation and
fibrosis through
lumican (LUM) and
decorin (DCN). In summation, our investigation provides compelling evidence affirming the therapeutic promise of Qiyin for
NAFLD. It elucidates the underlying mechanistic pathways, furnishing a compelling rationale for its prospective clinical application.