Alzheimer's disease is a
neurological disorder that causes increased
memory loss, mood swings, behavioral disorders, and disruptions in daily activities.
Polymer scaffolds for the brain have been grown under laboratory, physiological, and pathological circumstances because of the limitations of conventional treatments for patients with
central nervous system diseases. The blood-brain barrier prevents medications from entering the brain, challenging AD treatment. Numerous
biomaterials such as biomolecules,
polymers, inorganic metals, and
metal oxide nanoparticles have been used to transport therapeutic medicines into the nervous system. Incorporating
biocompatible materials that support neurogenesis through a combination of topographical, pharmacological, and mechanical stimuli has also shown promise for the transfer of cells to replenish dopaminergic neurons. Components made of naturally occurring biodegradable
polymers are appropriate for the regeneration of nerve tissue. The ability of natural-based materials (
biomaterials) has been shown to promote endogenous cell development after implantation. Also, strategic functionalization of polymeric nanocarriers could be employed for treating AD. In particular, nanoparticles could resolve Aβ aggregation and thus help cure
Alzheimer's disease. Drug moieties can be effectively directed to the brain by utilizing nano-based systems and diverse colloidal carriers, including
hydrogels and biodegradable scaffolds. Notably, early investigations employing neural stem cells have yielded promising results, further emphasizing the potential advancements in this field. Few studies have fully leveraged the combination of cells with cutting-edge
biomaterials. This study provides a comprehensive overview of prior research, highlighting the pivotal role of
biomaterials as sophisticated
drug carriers. It delves into various intelligent drug delivery systems, encompassing pH and thermo-triggered mechanisms, polymeric and
lipid carriers, inorganic nanoparticles, and other vectors. The discussion synthesizes existing knowledge and underscores the transformative impact of these
biomaterials in devising innovative strategies, augmenting current therapeutic methodologies, and shaping new paradigms in the realm of
Alzheimer's disease treatment.