A Targeted and Responsive Nanoprodrug Delivery System for Synergistic Glioma Chemotherapy.

Abstract

Doxorubicin (DOX) is widely used as a chemotherapeutic agent for both hematologic and solid tumors and is a reasonable candidate for glioma treatment. However, its effectiveness is hindered by significant toxicity and drug resistance. Moreover, the presence of the blood-brain barrier (BBB) brings a crucial challenge to glioma therapy. In response, a GSH-responsive and actively targeted nanoprodrug delivery system (cRGD/PSDOX-Cur@NPs) are developed. In this system, a disulfide bond-bridged DOX prodrug (PEG-SS-DOX) is designed to release specifically in the high glutathione (GSH) tumor environment, markedly reducing the cardiotoxicity associated with DOX. To further address DOX resistance, curcumin, serving as a P-glycoprotein (P-gp) inhibitor, effectively increased cellular DOX concentration. Consequently, cRGD/PSDOX-Cur@NPs exhibited synergistic anti-tumor effects in vitro. Furthermore, in vivo experiments validated the superior BBB penetration and brain-targeting abilities of cRGD/PSDOX-Cur@NPs, showcasing the remarkable potential for treating both subcutaneous and orthotopic gliomas. This research underscores that this nanoprodrug delivery system presents a novel approach to inhibiting glioma while addressing resistance and systemic toxicity.

• Authors: Weiling Zhuo, Wanyu Wang, Wenjie Zhou, Zhongxin Duan, Shi He, Xifeng Zhang, Linbin Yi, Rui Zhang, Anjie Guo, Xinyu Gou, Junli Chen, Ning Huang, Xiaodong Sun, Zhiyong Qian, Xiang Wang, Xiang Gao
• Journal: Small (Weinheim an der Bergstrasse, Germany) (Small) Pg. e2400630 (Mar 03 2024) ISSN: 1613-6829 [Electronic] Germany
• PMID: 38431937 (Publication Type: Journal Article)
• Copyright: © 2024 Wiley-VCH GmbH.