Abstract | BACKGROUND: Herpes simplex virus type 1 (HSV-1)-induced herpes simplex encephalitis (HSE) has a high mortality rate in clinically immunocompromised patients, while recovered patients often experience neurological sequelae due to neuroinflammation. Nucleoside drugs and nucleoside analogues such as acyclovir and ganciclovir are mainly used in clinical treatment, and the emergence of resistant viral strains makes the development of new anti-herpesvirus encephalitis drugs urgent. Resveratrol is a multifunctional, plant-derived bioactive compound and its antiviral potential is attracting much attention. PURPOSE: This study aimed to investigate the anti-HSV-1 mechanism of resveratrol in microglial cells and in the HSE mouse model. METHODS: RESULTS: CONCLUSION:
Resveratrol acted as a non-classical HSP90β inhibitor, binding to the STING-HSP90β interaction site to promote STING degradation and attenuate HSV-1-induced encephalitis and neuroinflammation. These findings suggest the alternative strategy of targeting HSP90β and resveratrol-mediated inhibition of HSP90β as a potential antiviral approach.
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Authors | Ziwei Huang, Shan Li, Lishan Zhong, Yuan Su, Menghe Li, Xiaohui Wang, Zexu Wang, Zhiping Wang, Cuifang Ye, Zhe Ren, Xiao Wang, Qiongzhen Zeng, Kai Zheng, Yifei Wang |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 127
Pg. 155476
(May 2024)
ISSN: 1618-095X [Electronic] Germany |
PMID | 38430586
(Publication Type: Journal Article)
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Copyright | Copyright © 2024 Elsevier GmbH. All rights reserved. |
Chemical References |
- Antiviral Agents
- Resveratrol
- NF-kappa B
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Topics |
- Animals
- Mice
- Humans
- Encephalitis, Herpes Simplex
(drug therapy, diagnosis)
- Antiviral Agents
(pharmacology, therapeutic use)
- Resveratrol
(pharmacology, therapeutic use)
- NF-kappa B
(metabolism)
- Neuroinflammatory Diseases
- Herpesvirus 1, Human
- Herpes Simplex
(drug therapy)
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