Identification of depression in patients with acute coronary syndrome using multiple serum biomarkers.

Abstract

BACKGROUND:

Biomarkers for depression in patients with acute coronary syndrome (ACS) have not been identified.

METHODS:

This study evaluated multiple serum biomarkers for depressive disorders after ACS. Thirteen serum biomarkers associated with seven functional systems, along with sociodemographic/clinical characteristics, were evaluated in 969 patients within 2 weeks after ACS onset (acute phase). In total, 711 patients were evaluated for depressive disorder using DSM-IV criteria 1 year later (chronic phase). Logistic regression was used for the analysis.

RESULTS:

Depressive disorders were observed in 378 patients (39.0%) in the acute phase of ACS and 183 patients (25.7%) in the chronic phase. The weighted scores of five serum biomarkers (high-sensitivity C-reactive protein, interleukin-6, homocysteine, troponin I, and creatine kinase-MB) were significantly associated with depressive disorder diagnosis in the acute phase, and the weighted scores of three other biomarkers (tumor necrosis factor-alpha, interleukin-1 beta, and homocysteine) were significantly associated with depressive disorders in the chronic phase, in a dose-dependent manner after adjusting for relevant covariates (all P-values <0.001).

CONCLUSIONS:

The combination of several serum biomarkers exhibited robust associations with depressive disorders in both the acute and chronic phases of ACS.

• Authors: Jae-Min Kim, Ju-Wan Kim, Hee-Ju Kang, Wonsuk Choi, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin, Youngkeun Ahn, Myung Ho Jeong
• Journal: General hospital psychiatry (Gen Hosp Psychiatry) 2024 May-Jun Vol. 88 Pg. 1-9 ISSN: 1873-7714 [Electronic] United States
• PMID: 38428184 (Publication Type: Journal Article)
• Copyright: Copyright © 2024 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• C-Reactive Protein
• Homocysteine

Topics

• Humans
• Acute Coronary Syndrome (complications)
• Depression (diagnosis, epidemiology)
• Biomarkers
• C-Reactive Protein (analysis)
• Homocysteine