Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy.

Abstract

In this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly (1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VA)) as matrix materials were developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment. In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were tested by Franz diffusion cells, showing an increase of the transdermal flux compared to passive diffusion due to the as-fabricated dissolving MNs having a sufficient mechanical strength to penetrate the skin and form microchannels. The pharmacological study in vivo showed that RB-loaded dissolving MNs significantly alleviated migraine-related response by up-regulating the level of 5-hydroxytryptamine (5-HT) and down-regulating the levels of calcitonin gene-related peptide (CGRP) and substance P (SP). In conclusion, the RB-loaded dissolving MNs have advantages of safety, convenience, and high efficacy over conventional administrations, laying a foundation for the transdermal drug delivery system treatment for acute migraine.

• Authors: Chao Zhong, Xiufeng Zhang, Yanfang Sun, Zhong Shen, Yanan Mao, Tianqi Liu, Rui Wang, Lei Nie, Amin Shavandi, Khaydar E Yunusov, Guohua Jiang
• Journal: Journal of biomaterials applications (J Biomater Appl) Vol. 38 Issue 9 Pg. 989-999 (Apr 2024) ISSN: 1530-8022 [Electronic] England
• PMID: 38427917 (Publication Type: Journal Article)

Chemical References

• rizatriptan
• Triazoles
• Tryptamines

Topics

• Humans
• Drug Delivery Systems
• Skin
• Administration, Cutaneous
• Migraine Disorders (drug therapy)
• Needles
• Triazoles
• Tryptamines