Potential of Targeting TDO2 as the Lung Adenocarcinoma Treatment.

Abstract

Tryptophan catabolism plays an important role in the metabolic reconnection in cancer cells to support special demands of tumor initiation and progression. The catabolic product of the tryptophan pathway, kynurenine, has the capability of suppressing the immune reactions of tumor cells. In this study, we conducted internal and external cohort studies to reveal the importance of tryptophan 2,3-dioxygenase (TDO) for lung adenocarcinoma (LUAD). Our study further demonstrated that the TDO2 expression was associated with the proliferation, survival, and invasion of LUAD cells, and targeting TDO2 for LUAD tumors could be a potential therapeutic strategy.

• Authors: Er Jin, Zhidong Yin, Xiuxiu Zheng, Chenhong Yan, Kai Xu, Fouejio Yemele Eunice, Yue Gao
• Journal: Journal of proteome research (J Proteome Res) Vol. 23 Issue 4 Pg. 1341-1350 (Apr 05 2024) ISSN: 1535-3907 [Electronic] United States
• PMID: 38421152 (Publication Type: Journal Article)

Chemical References

• Tryptophan Oxygenase
• Tryptophan
• Kynurenine

Topics

• Humans
• Tryptophan Oxygenase (genetics, metabolism)
• Tryptophan (metabolism)
• Kynurenine (metabolism)
• Adenocarcinoma of Lung (genetics)
• Lung Neoplasms (genetics)