Activity of a novel carotenoid analog, 4,4'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaen -1,18- diyl) bis(1-ethylpyridinium) dibromide (Y-18598) on mouse leukemia P388.

Abstract

4,4'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaen-1 ,18-diyl) bis (1-ethylpyridinium) dibromide (Y-18598), a novel carotenoid analog with 1-ethylpyridine rings as terminal groups, was found to be effective against P388 leukemia which was refractory to amphotericin B and retinoic acid used as representatives of polyene-containing drugs. The life span of leukemic mice was increased by 56% over the control following administration of 2.5 mg/kg on days 1-5. Among these polyene-containing compounds, Y-18598 was the most highly cytotoxic to P388 leukemia cells in vitro.

• Authors: T Okumoto, N Morita, I Nakamura, M Konishi, M Yamaguchi
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 109 Issue 3 Pg. 257-9 ( 1985) ISSN: 0171-5216 [Print] Germany
• PMID: 3839242 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Carotenoids
• Tretinoin
• Amphotericin B
• Y 18598
• Glucose

Topics

• Amphotericin B (therapeutic use)
• Animals
• Antineoplastic Agents (therapeutic use)
• Carotenoids (therapeutic use)
• Female
• Glucose (metabolism)
• Leukemia P388 (drug therapy)
• Leukemia, Experimental (drug therapy)
• Macrophages (metabolism)
• Mice
• Mice, Inbred Strains
• Tretinoin (therapeutic use)