Abstract | OBJECTIVE: To investigate the efficacy and safety of Venetoclax combined with CACAG regimen in treatment of patients with refractory/relapse acute myeloid leukemia(R/R AML). METHODS: The study was a singlecenter prospective clinical trial. The enrolled patients met the criteria for R/R AML. Treatment included Azacidine(75 mg/m2,d 1-7), Ara-C (75-100 mg/m2, q12h, d 1-5), Aclacinomycin(20 mg d1,d3,d5), Chidamide(30 mg d1,d4), Venetoclax(100 mg d1, 200 mg d2, 400 mg d3-d14, in combination with Triazole Drug, reduced to 100 mg/d), and granulocyte colony-stimulating factor (300 μg /d until neutrophil recovery). The primary endpoint of observation was overall response rate after 1 course of treatment. RESULTS: A total of 19 patients were enrolled from January 2022 to April 2023. After 1 course of treatmen, the overall response rate was 81.3%(13/16), the CR rate was 68.8%(11/16), and the PR was 12.5%(2/16). Among the 11 patients who got CR/CRi, 8 cases achieved CRm ( minimal residual disease negative CR) and 3 cases did not. As of March 27, 2023, the median follow-up time was 111(19-406) days. The six-month overall survival and progression-free survival rates were both 55.7%, the 1-year overall survival and progression-free survival rates were 46.4% and 47.7%, respectively. In addition, compared with the non-CRm group, CRm patients had a better PFS (377 days vs 111 days, P =0.046). Treatment-related adverse events were mainly 3-4 degrees of bone marrow suppression, complicated by various degrees of infection(n=12), hypokalemia(n=12) and hypocalcemia (n=10) and elevated liver enzymes (n=8), of which 3/4 degrees accounted for 47.4%(9/19). CONCLUSION: The Venetoclax combined with CACAG regimen is an effective salvage therapy for patients with R/R AML, with high remission rate and safety profile.
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Authors | Wen-Jing Gao, Jing-Jing Yang, Meng Li, Ya-Nan Wen, Yi-Fan Jiao, Ning LE, Yu-Chen Liu, Nan Wang, Sai Huang, Li-Ping Dou |
Journal | Zhongguo shi yan xue ye xue za zhi
(Zhongguo Shi Yan Xue Ye Xue Za Zhi)
Vol. 32
Issue 1
Pg. 90-95
(Feb 2024)
ISSN: 1009-2137 [Print] China |
PMID | 38387905
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- venetoclax
- Cytarabine
- Sulfonamides
- Bridged Bicyclo Compounds, Heterocyclic
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Topics |
- Humans
- Prospective Studies
- Leukemia, Myeloid, Acute
(drug therapy, etiology)
- Cytarabine
- Recurrence
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Sulfonamides
- Bridged Bicyclo Compounds, Heterocyclic
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