Abstract | Introduction: Methods: Results: Among the 11 patients with MN with active syphilis infection, positive NDNF staining was shown in 5 patients (46%). The remaining 6 patients demonstrated negative NDNF staining. Of these, 5 patients were PLA2R-positive and 1 patient was PLA2R-negative and NELL-1-negative. Antibiotics were also effective in 3 NDNF-negative patients, suggesting the possibility of syphilis-associated MN. Therefore, the histological positivity rate of NDNF was 63% (5/8 patients) in syphilis-associated MN. In addition, positive NDNF antibody was first confirmed in the serum of 1 patient with NDNF-associated MN. NDNF staining was negative in all 6 patients with MN with previous syphilis infection. Conclusion: Nearly half of the patients with active syphilis infection and MN were NDNF-positive in our study. Positive NDNF staining favors syphilis-associated MN. Circulating anti-NDNF antibody can be detected in the patient's serum sample. In addition, PLA2R or other unknown antigenic protein may also be the target antigens for syphilis-associated MN in Chinese population.
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Authors | Liyin Zhang, Minfang Zhang, Qionghong Xie, Yongxiang Wang, Zhaohui Ni, Shaojun Liu, Wenyan Zhou |
Journal | Kidney international reports
(Kidney Int Rep)
Vol. 9
Issue 2
Pg. 401-409
(Feb 2024)
ISSN: 2468-0249 [Electronic] United States |
PMID | 38344711
(Publication Type: Journal Article)
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Copyright | © 2023 International Society of Nephrology. Published by Elsevier Inc. |