Predicting suicidal ideation using multiple serum biomarkers in patients with acute coronary syndrome.

Abstract

BACKGROUND:

Biomarkers for suicidal behavior in patients with acute coronary syndrome (ACS) have yet to be elucidated. This study aimed to identify a panel of serum biomarkers associated with suicidal ideation (SI) in patients with ACS.

METHODS:

The study evaluated 969 patients within 2 weeks of ACS (acute phase) and 711 patients 12 months later (chronic phase). The evaluation included 14 serum biomarkers covering 7 functional systems, socio-demographic/clinical characteristics, and SI assessed by the "suicidal thoughts" item of the Montgomery-Åsberg Depression Rating Scale. Logistic regression models were used to analyze the data. The results showed that 195 patients (20.1 %) had SI in the acute phase, and 87 patients (12.2 %) had SI in the chronic phase.

RESULTS:

A combination of five serum biomarkers (tumor necrosis factor-α, interleukin-1β, folate, troponin I, and creatine kinase-MB) was significantly associated with SI in the acute phase, and a combination of three serum biomarkers (tumor necrosis factor-α, interleukin-1β, and folate) was significantly associated with SI in the chronic phase in a clear dose-dependent manner (all P-values < 0.001) after adjustment for relevant covariates.

DISCUSSION:

These findings suggest that the application of a combination of multiple serum biomarkers could improve the predictability of SI in patients with ACS at both acute and chronic phases.

• Authors: Jae-Min Kim, Ju-Wan Kim, Hee-Ju Kang, Wonsuk Choi, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin, Youngkeun Ahn, Myung Ho Jeong
• Journal: Journal of affective disorders (J Affect Disord) Vol. 351 Pg. 915-919 (Apr 15 2024) ISSN: 1573-2517 [Electronic] Netherlands
• PMID: 38342323 (Publication Type: Journal Article)
• Copyright: Copyright © 2024 Elsevier B.V. All rights reserved.

Chemical References

• Tumor Necrosis Factor-alpha
• Interleukin-1beta
• Biomarkers
• Folic Acid

Topics

• Humans
• Suicidal Ideation
• Acute Coronary Syndrome (diagnosis)
• Tumor Necrosis Factor-alpha
• Interleukin-1beta
• Biomarkers
• Folic Acid