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High-Dose Glucocorticoids for the Treatment of Sudden Hearing Loss.

Abstract
High-Dose Glucocorticoids for Sudden Hearing LossThis trial compared courses of high-dose intravenous prednisolone or high-dose oral dexamethasone versus standard-dose oral prednisone in adults with idiopathic sudden sensorineural hearing loss. At 30 days, systemic high-dose glucocorticoid therapy was not superior to a lower-dose regimen with respect to change in hearing threshold, and it was associated with a higher risk of side effects.
AuthorsStefan K Plontke, Matthias Girndt, Christoph Meisner, Imma Fischer, Iris Böselt, Jan Löhler, Beatrice Ludwig-Kraus, Michael Richter, Jörg Steighardt, Bernd Reuter, Christoph Böttcher, Jörg Langer, Wolfram Pethe, Ingmar Seiwerth, Nebojsa Jovanovic, Wilma Großmann, Andrea Kienle-Gogolok, Andreas Boehm, Marcus Neudert, Marc Diensthuber, Andreas Müller, Stefan Dazert, Orlando Guntinas-Lichius, Joachim Hornung, Veronika Vielsmeier, Joachim Stadler, Torsten Rahne, HODOKORT Trial Investigators
JournalNEJM evidence (NEJM Evid) Vol. 3 Issue 1 Pg. EVIDoa2300172 (Jan 2024) ISSN: 2766-5526 [Electronic] United States
PMID38320514 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Dexamethasone
  • Glucocorticoids
  • Prednisone
Topics
  • Adult
  • Humans
  • Dexamethasone
  • Glucocorticoids
  • Hearing Loss, Sudden (chemically induced)
  • Prednisone
  • Treatment Outcome

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