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Load-bearing columns inspired fabrication of ductile and mechanically enhanced BSA hydrogels.

Abstract
Currently, protein-based hydrogels are widely applied in soft materials, tissue engineering and implantable scaffolds owing to their excellent biocompatibility, and degradability. However, most protein-based hydrogels are soft brittle. In this study, a ductile and mechanically enhanced bovine serum albumin (BSA) hydrogel is fabricated by soaking the a 1-(3-dimethylaminopropyl)-3ethylcarbodiimide hydrochloride/N-hydroxysuccinimide (EDC/NHS) induced BSA hydrogel in (NH4)2SO4 solution. An EDC/NHS coupling reaction induce protein coupling reactions that cause the BSA skeleton to resemble architectural load-bearing walls, protecting the integrity of the hydrogel and preventing collapse. The effects of the BSA and (NH4)2SO4 concentrations on the hydrogel mechanics are evaluated, and the possible strengthening mechanism is discussed. Besides, the highly kosmotropic ions greatly enhance the hydrophobic interaction within BSA gels and dehydration effect and their mechanical properties were significantly enhanced. The various mechanical properties of hydrogels can be regulated over a large window by soaking hydrogels into various ions. And most of them can be washed away, maintaining high biocompatibility of the protein. Importantly, the protein hydrogels prepared by this strategy could also be modified as strain sensors. In a word, this work demonstrates a new, universal method to provide multi-functional, biocompatible, strength enhanced and regulable mechanical pure protein hydrogel, combining the Hofmeister effect with -NH2/-COOH association groups.
AuthorsShengyu Li, Lihong Gong, Xijin Wu, Xianli Liu, Ningning Bai, Yingxue Guo, Xia Liu, Hong Zhang, Huiying Fu, Qiyang Shou
JournalInternational journal of biological macromolecules (Int J Biol Macromol) Vol. 261 Issue Pt 2 Pg. 129910 (Mar 2024) ISSN: 1879-0003 [Electronic] Netherlands
PMID38309395 (Publication Type: Journal Article)
CopyrightCopyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.
Chemical References
  • Serum Albumin, Bovine
  • Hydrogels
  • Ions
Topics
  • Serum Albumin, Bovine (chemistry)
  • Hydrogels (chemistry)
  • Tissue Engineering
  • Tensile Strength
  • Ions

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