Tumor development and
metastasis are closely related to the complexity of the metabolism network. Recently, metabolism reprogramming strategies have attracted much attention in
tumor metabolism
therapy. Although there is preliminary success of metabolism
therapy agents, their
therapeutic effects have been restricted by the effective reaching of the
tumor sites of drugs. Nanodelivery systems with unique physical properties and elaborate designs can specifically deliver to the
tumors. In this review, we first summarize the research progress of nanodelivery systems based on
tumor metabolism reprogramming strategies to enhance
therapies by depleting
glucose, inhibiting glycolysis, depleting
lactic acid, inhibiting lipid metabolism, depleting
glutamine and
glutathione, and disrupting
metal metabolisms combined with other
therapies, including
chemotherapy,
radiotherapy,
photodynamic therapy, etc. We further discuss in detail the advantages of nanodelivery systems based on
tumor metabolism reprogramming strategies for
tumor therapy. As well as the opportunities and challenges for integrating nanodelivery systems into
tumor metabolism
therapy, we analyze the outlook for these emerging areas. This review is expected to improve our understanding of modulating
tumor metabolisms for enhanced
therapy.