Laparoscopic Portal Vein Ligation and Embolization During First-Stage Hepatectomy for Initially Unresectable Colorectal Liver Metastases.

Abstract

BACKGROUND:

Two-stage hepatectomy (TSH) is the only treatment for the patients with multiple bilobar colorectal liver metastases (CRMs) who are not candidates for one-step hepatectomy because of insufficient future remnant liver volume and/or impaired liver function.1-5 Although laparoscopic approaches have been introduced for TSH,6-8 the postoperative morbidity and mortality remains high because of the technical difficulties during second-stage hepatectomy.9,10 The authors present a video of laparoscopic TSH with portal vein (PV) ligation and embolization, which minimizes adhesions and PV thrombosis risk in the remnant liver, thereby facilitating second-stage hepatectomy.

METHODS:

Three patients with initially unresectable bilateral CRMs received a median of chemotherapy 12 cycles, followed by conversion TSH. After right PV ligation, laproscopic PV embolization was performed by injection of 100% ethanol into the hepatic side of the right PV using a 23-gauge winged needle. After PV embolization, a spray adhesion barrier (AdSpray, Terumo, Tokyo, Japan)11 was applied.

RESULTS:

During the first stage of hepatectomy, two patients underwent simultaneous laparoscopic colorectal resection (left hemicolectomy and high anterior resection). In the initial hepatectomy, two patients underwent two limited hepatectomies each, and one patient underwent six hepatectomies in the left lobe. After hepatectomy, all the patients underwent right PV embolization. During the second stage, two patients underwent open extended right hepatectomy (right adrenalectomy was performed because of adrenal invasion in one patient), and one patient underwent laparoscopic extended right hepatectomy. No postoperative complications occurred in the six surgeries.

CONCLUSIONS:

Laparoscopic TSH with PV embolization is recommended for safe completion of the second hepatectomy.

• Authors: Yoshihiro Ono, Yosuke Inoue, Kosuke Kobayashi, Shoki Sato, Yuki Kitano, Atsushi Oba, Takafumi Sato, Hiromichi Ito, Yu Takahashi
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 31 Issue 5 Pg. 3069-3070 (May 2024) ISSN: 1534-4681 [Electronic] United States
• PMID: 38291303 (Publication Type: Journal Article)
• Copyright: © 2024. Society of Surgical Oncology.

Chemical References

• Thyrotropin

Topics

• Humans
• Hepatectomy
• Portal Vein (surgery)
• Colorectal Neoplasms (pathology)
• Liver Neoplasms (surgery)
• Laparoscopy
• Embolization, Therapeutic
• Ligation
• Thyrotropin
• Treatment Outcome