Metastatic castration resistant prostate cancer patients' experience with Radium-223 treatment in Japan.

Abstract

Aim: We aimed to determine Japanese metastatic castration resistant prostate cancer (CRPC) patients' Ra-223 treatment experience. Patients & methods: Patients answered the Cancer Therapy Satisfaction Questionnaire (CTSQ domains: Satisfaction with Therapy [SWT], Expectations of Therapy [ET], Feelings about Side Effects [FSE]), the Memorial Anxiety Scale for Prostate Cancer (MAX-PC) and the FACT-Bone Pain (FACT-BP) Questionnaire at baseline, during (vists 3 and 5) and after treatment (end of observation; EOO). Results: Data from 72 patients were included. Baseline median CTSQ scores SWT: 66.1 (IQR19.7), ET: 75.0 (IQR45), and FSE 68.8 (IQR 34.4) were unchanged during vists 3 and 5, but the SWT (-3.57 [IQR17.9]) and ET (-5.0 [IQR30]) decreased while FSE was unchanged (0.0 [IQR31.25]) at EOO. The median MAX-PC (18.0 [IQR 49]) score was unchanged (0.0, IQR 6) while the median FACT BP (54.0 [IQR13]) score decreased by -1.0 (IQR 8) at EOO. Conclusion: Japanese metastatic castration resistant prostate cancer patients' experience is stable during Ra-223 treatment.

• Authors: Koichiro Akakura, Hiroji Uemura, Satoru Kawakami, Akira Yokomizo, Motonobu Nakamura, Kazuo Nishimura, Tetsushi Komori, Dianne Athene Ledesma
• Journal: Future oncology (London, England) (Future Oncol) Vol. 20 Issue 12 Pg. 781-798 (Apr 2024) ISSN: 1744-8301 [Electronic] England
• PMID: 38275149 (Publication Type: Journal Article)

Chemical References

• Radium-223
• Radium

Topics

• Male
• Humans
• Prostatic Neoplasms, Castration-Resistant (radiotherapy)
• Radium (adverse effects)
• Japan (epidemiology)
• Quality of Life
• Bone Neoplasms (radiotherapy)