Role of renal tubular epithelial cells and macrophages in cisplatin-induced acute renal injury.

Abstract

Acute kidney injury (AKI) is a clinical syndrome characterized by a sudden and continuous decline in renal function. The drug cisplatin is commonly used as chemotherapy for solid tumors, and cisplatin-induced acute kidney injury (CI-AKI), which is characterized by acute tubular necrosis and inflammation, frequently occurs in tumor patients. Renal tubular epithelial cells (RTECs) are severely damaged early in this process and play an important role in renal tubular injury and the recruitment of immune cells. Macrophages are the most common infiltrating immune cells in the kidney and have a significant impact on CI-AKI and subsequent repair. This article reviews the latest research progress on the effects of RTECs and macrophages on CI-AKI and their interactions in AKI to provide a direction for identifying therapeutic targets for treating AKI.

• Authors: Jinzhang Gao, Qinxiang Deng, Jun Yu, Chun Wang, Wei Wei
• Journal: Life sciences (Life Sci) Vol. 339 Pg. 122450 (Feb 15 2024) ISSN: 1879-0631 [Electronic] Netherlands
• PMID: 38262575 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2024 Elsevier Inc. All rights reserved.

Chemical References

• Cisplatin

Topics

• Humans
• Cisplatin (toxicity)
• Acute Kidney Injury (pathology)
• Kidney (pathology)
• Macrophages (pathology)
• Epithelial Cells (pathology)