Abstract | BACKGROUND:
Thyroid hormones have been indicated to be associated with depression, but their relationship with poststroke depression (PSD) remains controversial. Therefore, we performed a meta-analysis to explore the correlation between thyroid hormone levels in acute stroke and PSD. METHODS: RESULTS: A total of 13 studies were included in the analysis. Compared to non-PSD patients, PSD patients had remarkably lower serum TSH and FT3 levels (TSH: SMD = -0.59, 95%CI = -1.04 to -.15, p = .009; FT3: SMD = -0.40, 95%CI = -.51 to -.30, p = .000) and higher serum FT4 levels (SMD = 0.33, 95%CI = .07-.59, p = .013). Subgroup analysis showed that there may be a more statistically significant association between FT3 and the risk of PSD compared to TSH and FT4. CONCLUSIONS: Our results suggested that patients with lower serum TSH and FT3 levels as well as higher serum FT4 levels in the acute stage of stroke may be more susceptible to PSD.
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Authors | Jie Fu, Qin Zhao, Jinglun Li, Xiu Chen, Lilei Peng |
Journal | Brain and behavior
(Brain Behav)
Vol. 14
Issue 1
Pg. e3322
(01 2024)
ISSN: 2162-3279 [Electronic] United States |
PMID | 38189637
(Publication Type: Meta-Analysis, Journal Article, Review, Research Support, Non-U.S. Gov't)
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Copyright | © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. |
Chemical References |
- Thyroid Hormones
- Thyrotropin
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Topics |
- Humans
- Depression
(etiology)
- Thyroid Hormones
- Thyrotropin
- Stroke
(complications)
- Databases, Factual
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