Abstract | OBJECTIVE: METHODS: We collected demographic and clinical data and serum samples from 497 patients with colorectal adenoma, 955 patients with colorectal cancer, and 911 healthy individuals from the First Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang Cancer Hospital, Zhuji People's Hospital, and Lin'an District First People's Hospital. Instrumental variables of leptin were selected and genotyping tests were performed. A logistic regression model and stratified analysis were used to evaluate the association of serum leptin levels with colorectal adenoma, colorectal cancer, and the progression of colorectal adenoma to colorectal cancer. Genetic risk score (GRS) and single nucleotide polymorphisms (SNPs) were further used as instrumental variables in one-sample and two-sample Mendelian randomization analyses leveraging two-stage least squares and inverse-variance weighted methods to estimate the causal association of leptin levels with the risk of colorectal adenoma, colorectal cancer, and progression of colorectal adenoma to colorectal cancer. RESULTS: CONCLUSION:
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Authors | H Zhao, Y Ling, S Mi, J Zhu, J Fan, Y Yang, J Wang, Y Li |
Journal | Nan fang yi ke da xue xue bao = Journal of Southern Medical University
(Nan Fang Yi Ke Da Xue Xue Bao)
Vol. 43
Issue 12
Pg. 1989-1997
(Dec 20 2023)
ISSN: 1673-4254 [Print] China |
PMID | 38189383
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Humans
- Leptin
- Case-Control Studies
- Mendelian Randomization Analysis
- Adenoma
(genetics)
- Colorectal Neoplasms
(genetics)
- Genetic Risk Score
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