Abstract | OBJECTIVES: METHODS: RESULTS: During a median follow-up of 12 y, 4510 participants developed new-onset severe liver disease. Overall, there was an inverse association of serum 25( OH)D with new-onset severe liver disease (per SD increment, adjusted hazard ratio [HR], 0.87; 95% confidence interval, 0.84-0.91). Similarly, serum 25( OH)D (per SD increment) was significantly and inversely associated with new-onset compensated cirrhosis, decompensated cirrhosis, liver failure, and liver-related death, respectively, with HRs ranging from 0.75 to 0.87. No significant association was found for hepatocellular carcinoma. Furthermore, there was a stronger inverse association between serum 25( OH)D and severe liver disease among those with a higher FIB-4 score (≥2.67, 1.3 to <2.67, and <1.3; Pinteraction < 0.001). However, the genetic risks for liver cirrhosis, calculated using 12 related single nucleotide polymorphisms, did not significantly modify the association between serum 25( OH)D and severe liver disease (Pinteraction = 0.216). CONCLUSIONS: Lower serum 25( OH)D concentrations were significantly associated with a greater risk for new-onset severe liver disease, especially in participants with higher FIB-4 scores.
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Authors | Chun Zhou, Yanjun Zhang, Ziliang Ye, Panpan He, Yuanyuan Zhang, Xiaoqin Gan, Sisi Yang, Mengyi Liu, Qimeng Wu, Xianhui Qin |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
Vol. 119
Pg. 112320
(Mar 2024)
ISSN: 1873-1244 [Electronic] United States |
PMID | 38185094
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Elsevier Inc. All rights reserved. |
Chemical References |
- 25-hydroxyvitamin D
- Vitamin D
- Calcifediol
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Topics |
- Humans
- Carcinoma, Hepatocellular
(genetics, complications)
- Vitamin D Deficiency
- Vitamin D
(analogs & derivatives)
- Calcifediol
- Liver Cirrhosis
(genetics)
- Liver Failure
(complications)
- Liver Neoplasms
(genetics, complications)
- Genetic Predisposition to Disease
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