Abstract |
Interleukin (IL)-22 is unique among the ILs as it elicits direct effects on kidney epithelia and regulates cell survival in a context-dependent manner. Studies published in Kidney International and other journals demonstrate opposing roles of IL-22 (e.g., in models of acute kidney injury). In the early necroinflammation phase of acute kidney injury, IL-22 promotes tubular cell death, whereas it enhances the proliferation and regeneration of epithelial barrier function in the healing phase of injured tubules.
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Authors | Hans-Joachim Anders, Joachim Andrassy, Julia Lichtnekert |
Journal | Kidney international
(Kidney Int)
Vol. 105
Issue 1
Pg. 22-25
(Jan 2024)
ISSN: 1523-1755 [Electronic] United States |
PMID | 38182296
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved. |
Topics |
- Humans
- Acute Kidney Injury
(etiology)
- Kidney
- Cell Death
- Cell Survival
- Epithelial Cells
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