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Regulators of necroinflammation in acute kidney injury.

Abstract
Interleukin (IL)-22 is unique among the ILs as it elicits direct effects on kidney epithelia and regulates cell survival in a context-dependent manner. Studies published in Kidney International and other journals demonstrate opposing roles of IL-22 (e.g., in models of acute kidney injury). In the early necroinflammation phase of acute kidney injury, IL-22 promotes tubular cell death, whereas it enhances the proliferation and regeneration of epithelial barrier function in the healing phase of injured tubules.
AuthorsHans-Joachim Anders, Joachim Andrassy, Julia Lichtnekert
JournalKidney international (Kidney Int) Vol. 105 Issue 1 Pg. 22-25 (Jan 2024) ISSN: 1523-1755 [Electronic] United States
PMID38182296 (Publication Type: Journal Article)
CopyrightCopyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Topics
  • Humans
  • Acute Kidney Injury (etiology)
  • Kidney
  • Cell Death
  • Cell Survival
  • Epithelial Cells

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