Abstract | BACKGROUND: METHODS: Participants with AF from ARIC visit 5 (2011-2013) were included in the study. Multiple linear regression was used to estimate the association of high sensitivity troponin (hs- TnT), N-terminal fragment B-type natriuretic peptide ( NT-proBNP) and high sensitivity C-reactive protein ( hsCRP) levels with self-reported fatigue (SF-12 and PROMIS Fatigue Scale), depressive symptoms (Center for Epidemiological Studies Depression survey), and physical functioning (Short Physical Performance Battery) scores. All biomarkers underwent natural-log transformation. RESULTS: There were 446 participants (mean age: 78 y ± 5; 44% women). In adjusted analyses, NT-proBNP was associated with AF- fatigue (β: 0.11, 95% CI: 0.03, 0.19), increased depressive symptoms (β: 0.44, 95% CI: 0.19, 0.70), and decreased physical function (β: -0.48, 95% CI: -0.72, -0.23). Hs- TnT was also associated with elevated AF- fatigue (β: 0.24, 95% CI: 0.09, 0.39) along with decreased physical function (β: -1.19, 95% CI: -1.64, -0.75). No significant associations were found with hsCRP and fatigue. CONCLUSION: Increased levels of cardiac injury biomarkers, depressive symptoms, and decreased physical function were associated with AF- fatigue. Inflammation was not associated with AF- fatigue; other physiological pathways, such as cardiac overload or myocardial injury may be more relevant in AF- fatigue.
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Authors | Kathryn A Wood, Aniqa B Alam, Lin Yee Chen, Elsayed Z Soliman, Arshed A Quyyumi, Alvaro Alonso |
Journal | Biological research for nursing
(Biol Res Nurs)
Pg. 10998004231225442
(Jan 02 2024)
ISSN: 1552-4175 [Electronic] United States |
PMID | 38166254
(Publication Type: Journal Article)
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