Influence of left ventricular ejection fraction in patients undergoing contemporary pLVAD-supported high-risk PCI.

Abstract

BACKGROUND:

Left ventricular (LV) systolic dysfunction worsens outcomes in patients undergoing percutaneous coronary intervention (PCI). The objective of this study, therefore, was to evaluate outcomes of pLVAD-supported high-risk PCI (HRPCI) patients according to LV ejection fraction (LVEF).

METHODS:

Patients from the PROTECT III study undergoing pLVAD-supported HRPCI were stratified according to baseline LVEF: severe LV dysfunction (LVEF <30%), mild and moderate LV dysfunction (LVEF ≥30% to <50%), or preserved LV function (LVEF ≥50%). Major adverse cardiovascular and cerebrovascular events (MACCE: composite of all-cause death, myocardial infarction, stroke/transient ischemic attack, and repeat revascularization), and PCI-related complications were assessed at 90 days and mortality was assessed at 1-year.

RESULTS:

From March 2017 to March 2020, 940 patients had evaluable baseline LVEF recorded in the study database. Patients with preserved LV function were older, more frequently presented with myocardial infarction, and underwent more left main PCI and atherectomy. Immediate PCI-related coronary complications were infrequent (2.7%, overall), similar between groups (P = 0.98), and not associated with LVEF. Unadjusted 90-day MACCE rates were similar among LVEF groups; however, as a continuous variable, LVEF was associated with both 90-day MACCE (adj.HR per 5% 0.89, 95% CI [0.80, 0.98], P = 0.018) and 1-year mortality (adj.HR per 5% 0.84 [0.78, 0.90], P <0.0001).

CONCLUSIONS:

Patients who underwent pLVAD-supported HRPCI exhibited low incidence of PCI-related complications, regardless of baseline LVEF. However, LVEF was associated with 90-day MACCE and 1-year mortality.

• Authors: Arsalan Abu-Much, Cindy L Grines, Wayne B Batchelor, Aneel S Maini, Yiran Zhang, Björn Redfors, Lavanya Bellumkonda, Aditya S Bharadwaj, Jeffrey W Moses, Alexander G Truesdell, Yanru Li, Suzanne J Baron, Alexandra J Lansky, Mir B Basir, David J Cohen, William W O'Neill
• Journal: American heart journal (Am Heart J) Vol. 269 Pg. 139-148 (Mar 2024) ISSN: 1097-6744 [Electronic] United States
• PMID: 38151142 (Publication Type: Journal Article)
• Copyright: Copyright © 2023. Published by Elsevier Inc.

Topics

• Humans
• Stroke Volume
• Ventricular Function, Left
• Percutaneous Coronary Intervention
• Treatment Outcome
• Myocardial Infarction (complications)
• Ventricular Dysfunction, Left
• Coronary Artery Disease (complications)