Histochemical and ultrastructural study of renal cortical necrosis in rats treated with oestrone + vasopressin, and its prevention with a vasopressin antagonist.

Abstract

Renal cortical necrosis was induced by the administration of vasopressin to oestrogen-pretreated rats. Histochemical (succinic dehydrogenase, trichrome, perjod acid Schiff) and electronmicroscopic methods were applied to examine how the vasopressin antagonist d(CH2)5Tyr(Met)AVP influences the development of this renal cortical necrosis. The experiments revealed that vasopressin did not induce hypoxia or necrosis in the renal tubules if the antagonist was administered simultaneously, even after oestrogen pretreatment. The conclusion is drawn that this pressor antagonist may be of value for the prevention of renal cortical necrosis in rats or in human beings.

• Authors: J Kocsis, G Karácsony, S Karcsú, F A László
• Journal: British journal of experimental pathology (Br J Exp Pathol) Vol. 68 Issue 1 Pg. 35-43 (Feb 1987) ISSN: 0007-1021 [Print] England
• PMID: 3814500 (Publication Type: Journal Article)

Chemical References

• Arginine Vasopressin
• Estrone
• Lypressin
• vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine-

Topics

• Animals
• Arginine Vasopressin (analogs & derivatives, pharmacology)
• Disease Models, Animal
• Estrone (pharmacology)
• Histocytochemistry
• Kidney (analysis)
• Kidney Cortex Necrosis (chemically induced, pathology, prevention & control)
• Lypressin (antagonists & inhibitors, pharmacology)
• Male
• Microscopy, Electron
• Rats
• Rats, Inbred Strains