Paradoxical worsening of ocular symptoms after transvenous embolization of cavernous sinus dural arteriovenous fistula due to coil-induced perifocal inflammation: A case report.

Abstract

Ocular symptoms usually completely resolve after successful transvenous embolization of cavernous sinus dural arteriovenous fistulas (CS-dAVFs). Herein, we report a case of CS-dAVF in which sinus packing of the superior ophthalmic vein (SOV) caused coil-induced inflammation in orbital tissue, leading to deteriorating ocular symptoms. A 73-year-old woman presented with right-eye exophthalmos and chemosis. Cerebral angiography demonstrated right CS-dAVF, which retrogradely drained into the right SOV. We conducted sinus packing with coils via the right inferior petrosal sinus, resulting in obliteration of the shunts. One day after sinus packing, right exophthalmos and chemosis progressed, suggesting dAVF recurrence. However, no residual angiographic shunts were observed. Orbital magnetic resonance imaging (MRI) revealed edema in intraorbital tissue and gadolinium contrast enhancement of SOV wall. We presumed that the coils in SOV induced perifocal inflammation at the venous wall and surrounding orbital tissue, leading to aggravation of ocular symptoms. Following steroid therapy for 2 months, ocular symptoms and contrast enhancement on orbital MRI significantly improved without anticoagulant treatment. Posttreatment paradoxical worsening of ocular symptoms could be caused by coil-induced inflammation of the SOV wall near the orbital tissue. Steroid therapy could be effective in reducing orbital inflammatory reactions.

• Authors: Norihiro Iwamoto, Hiroyuki Sakata, Masayuki Ezura, Yoshinari Osada, Hidenori Endo, Teiji Tominaga
• Journal: Clinical neurology and neurosurgery (Clin Neurol Neurosurg) Vol. 236 Pg. 108086 (Jan 2024) ISSN: 1872-6968 [Electronic] Netherlands
• PMID: 38128258 (Publication Type: Case Reports)
• Copyright: Copyright © 2023 Elsevier B.V. All rights reserved.

Chemical References

• Steroids

Topics

• Female
• Humans
• Aged
• Cavernous Sinus (diagnostic imaging)
• Central Nervous System Vascular Malformations (diagnostic imaging, therapy)
• Cranial Sinuses
• Exophthalmos (etiology)
• Embolization, Therapeutic (adverse effects, methods)
• Inflammation (etiology, therapy)
• Steroids