Abstract | INTRODUCTION: CASE: A 45-year-old man presented with headache, fever, backache, dysuria, tremble of hands, numbness of lower limbs, without diplopia, decreased vision, or other manifestations of optic neuritis. He was initially diagnosed with viral meningitis. After antiviral therapy, his headache, fever, and dysuria were improved, but the tremble of his upper limbs and numbness of his lower limbs still existed. A lumbar puncture was further performed and found both anti-GFAP and anti-MOG antibodies in the cerebrospinal fluid. No evidence of other immune disorders or infectious diseases was revealed. Meanwhile, a magnetic resonance scan showed enhancement of spinal pia mater in cervical, thoracic, and lumbar segments. He was then treated with immunoglobulin (intravenous immunoglobulin) therapy (25 g for 5 d), and steroid pulse therapy ( methylprednisolone, 1 g for 5 d), followed by a gradual tapering of oral prednisolone. CONCLUSION: We reported a case of overlapping anti-GFAP and anti-MOG antibody-associated syndrome. This case enriches our understanding of the clinical manifestations of overlapping syndrome and expands the spectrum of this disorder.
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Authors | Danmei Pan, Jina Gu, Chengjun Zeng, Lin Chen |
Journal | The neurologist
(Neurologist)
(Dec 21 2023)
ISSN: 2331-2637 [Electronic] United States |
PMID | 38126409
(Publication Type: Journal Article)
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