Abstract | Objective: Semaphorin3E (Sema3E) mediates reorganization of the actin cytoskeleton, and plays an important role in ensuring the specificity of synapse formation and angiogenesis. However, the role of Sema3E in allergic asthma (AS) and eosinophilic bronchitis (EB) is still elusive. This study aimed to investigate the relationship between Sema3E in vagal ganglion and lung tissue, airway reactivity, and eosinophilic inflammation. Methods: The frequency of coughs and airway reactivity as well as the airway inflammation were observed in ovalbumin- (OVA-) induced AS and EB mouse models. The expression of Sema3E was examined in the vagal ganglion and lung tissues by immunofluorescence staining and western blotting analyses. In the Sema3E treatment protocol, exogenous Sema3E was administrated intranasally before challenge in AS model to study the effect of Sema3E on airway hyperresponsiveness, airway inflammation, mucus production, and collagen deposition. Results: Conclusion: Sema3E in lungs and vagal ganglia is related to eosinophilic inflammation and has a protective effect on OVA-induced AHR in asthma.
|
Authors | Liyan Chen, Xiaohui Yuan, Yaowei He, Zichuan Fan, Ya Guan, Qiuying Li, Yaying Chen, Lianglan Bao, Yidan Huang, Kefang Lai |
Journal | Journal of immunology research
(J Immunol Res)
Vol. 2023
Pg. 6459234
( 2023)
ISSN: 2314-7156 [Electronic] Egypt |
PMID | 38111650
(Publication Type: Journal Article)
|
Copyright | Copyright © 2023 Liyan Chen et al. |
Chemical References |
|
Topics |
- Mice
- Animals
- Asthma
(metabolism)
- Lung
(metabolism)
- Respiratory Hypersensitivity
- Inflammation
(metabolism)
- Disease Models, Animal
- Eosinophilia
- Cough
(metabolism)
- Collagen
(metabolism)
- Ovalbumin
- Bronchoalveolar Lavage Fluid
- Mice, Inbred BALB C
|