Maximum carotid intima-media thickness and NT-pro BNP in association with retinal vein occlusion.

Abstract

The purpose is to clarify the relationship between patients with retinal vein occlusion (RVO), maximal intima-media complex thickness (Max IMT), and N-terminal pro-brain natriuretic peptide (NT-proBNP), which is useful in assessing atherosclerosis. This was a retrospective observation, single center study. The patients were 86 RVO patients (male: female = 43:43, mean age 63.3 years), 25 with central retinal vein occlusion (CRVO) and 61 with branch retinal vein occlusion (BRVO), classified as ≧50 years old and <50 years old, Max IMT≧1.1 and less, NT-pro BNP≧55 and less. Results showed that Max IMT ≧1.1 was significantly more common in both the CRVO and BRVO groups at ≧50 years, and NT-pro BNP ≧55 was significantly more common in the CRVO group. Max IMT≧1.1 was seen in 80% of the BRVO group and in 85% of patients aged ≧50 years. Sixty-eight percent of patients in the CRVO group had Max IMT≧1.1, but none of those < 50 years had Max IMT≧1.1. Forty-eight percent of RVO patients had NT-pro BNP≧55, and significantly more patients had Max IMT≧1.1 than those who did not have NT-pro BNP more than 55 (p = 0.02). Multiple regression analysis with Max IMT as the dependent variable showed that age and NT-pro BNP were significantly associated with RVO (p = 0.015, 0.022). RVO patients were more likely to have a Max IMT≧1.1, which was associated with atherosclerosis. Max IMT and NT-pro BNP were also associated with RVO patients, so NT-pro BNP may be a marker of RVO.

• Authors: Hajime Onoe, Koji Tanaka, Norihiro Tsuchiya, Keisuke Miyata, Mai Kitaoka, Mao Nakayama, Ryusaburo Mori, Hiroyuki Nakashizuka
• Journal: PloS one (PLoS One) Vol. 18 Issue 12 Pg. e0291456 ( 2023) ISSN: 1932-6203 [Electronic] United States
• PMID: 38096214 (Publication Type: Journal Article)
• Copyright: Copyright: © 2023 Onoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Chemical References

• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Humans
• Male
• Female
• Aged
• Middle Aged
• Retinal Vein Occlusion (complications)
• Natriuretic Peptide, Brain
• Carotid Intima-Media Thickness
• Retrospective Studies
• Atherosclerosis (complications)