Abstract | BACKGROUND: This retrospective study was performed to investigate the survival differences according to the pathologic status after neoadjuvant chemotherapy followed by surgery in esophageal squamous cell carcinoma (ESCC), and to investigate whether current AJCC 8th ypStage can predict survival accurately. METHODS: RESULTS: The mean age was 62.00 ± 8.01 years, of which 524 (93.1%) were males. The median follow-up period was 29.12 months. A total of 153 (27.1%) patients showed pathologic complete response (pCR) and 92 (16.3%) patients showed pCR of the primary lesion with residual metastatic lymph nodes (ypT0N +). A total of 196 (35%) and 122 (21.6%) patients showed ypT + N + and ypT + N, respectively. The 5-year overall survival (OS) of each group was 75.1% (CR), 42.4% (ypT + N0), 54.9% (ypT0N +), and 26.1% (ypT + N +); CR patients showed better survival than the other groups, and no survival differences were found in the 5-year OS between ypT + N0 and ypT0N + patients (p = 0.811). In ypStage I, there were survival differences between ypT0N0 and ypTis-2N0 patients, and ypT1N0 (ypStage I) and ypT0N1 (ypStageIIIA) showed similar OS (5-year OS in 49.3% vs. 67.1%, p = 0.623). CONCLUSIONS: pCR offers long-term survival in patients; however, survival significantly declines with the presence of residual primary lesion and nodal metastases.
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Authors | Seong Yong Park, Junghee Lee, Dongryul Oh, Jong-Mu Sun, Jeonghee Yun, Yeong Jeong Jeon, Jong Ho Cho, Yong Soo Choi, Jae Il Zo, Young Mog Shim, Hong Kwan Kim |
Journal | Esophagus : official journal of the Japan Esophageal Society
(Esophagus)
Vol. 21
Issue 1
Pg. 51-57
(Jan 2024)
ISSN: 1612-9067 [Electronic] Japan |
PMID | 38082188
(Publication Type: Journal Article)
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Copyright | © 2023. The Author(s) under exclusive licence to The Japan Esophageal Society. |
Topics |
- Male
- Humans
- Middle Aged
- Aged
- Female
- Esophageal Squamous Cell Carcinoma
(pathology)
- Prognosis
- Neoadjuvant Therapy
- Retrospective Studies
- Esophageal Neoplasms
(pathology)
- Carcinoma, Squamous Cell
(pathology)
- Neoplasm Staging
- Pathologic Complete Response
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