Resistance analysis following sotrovimab treatment in participants with COVID-19 during the phase III COMET-ICE study.

Abstract

Aim: Sotrovimab is an engineered human monoclonal antibody that binds a conserved region of the SARS-CoV-2 spike protein. The COMET-ICE phase III study evaluated sotrovimab for treatment of mild to moderate COVID-19 in nonhospitalized participants with ≥1 risk factor for severe disease progression. Materials & methods: We evaluated the presence of circulating SARS-CoV-2 variants of concern or interest (VOCs/VOIs) and characterized the presence of baseline, post-baseline and emergent amino acid substitutions detected in the epitope of sotrovimab in SARS-CoV-2. Results: None of the sotrovimab-treated participants with baseline epitope substitutions, and 1 of 48 sotrovimab-treated participants with post-baseline epitope substitutions, met the primary clinical endpoint for progression. Conclusion: Overall, progression was not associated with identified VOC/VOI or the presence of epitope substitutions in sotrovimab-treated participants.

• Authors: Sambhavi Subramanian, Gretja Schnell, Julia di Iulio, Anil K Gupta, Adrienne E Shapiro, Elias H Sarkis, Amanda Lopuski, Amanda Peppercorn, Melissa Aldinger, Christy M Hebner, Andrea L Cathcart
• Journal: Future virology (Future Virol) (Nov 2023) ISSN: 1746-0794 [Print] England
• PMID: 38074312 (Publication Type: Journal Article)
• Copyright: © 2023 The Authors.