Combined utility of Ki-67 index and tumor grade to stratify patients with pancreatic ductal adenocarcinoma who underwent upfront surgery.

Abstract

OBJECTIVE:

To investigate the prognostic prediction of a new indicator, combined by tumor grade and Ki-67, in patients with resected pancreatic ductal adenocarcinoma (PDAC).

METHODS:

Data were retrospectively collected from consecutive patients who underwent primary resection of pancreas from December 2012 to December 2017. Tumor grade and Ki-67 were reviewed from routine pathological reports. G-Ki67 was classified as three categories as I (G1/2 and Ki-67 < 40%), II (G1/2 and Ki-67 ≥ 40%), and III(G3/4 and all Ki-67).

RESULTS:

Cox regression analyses revealed that tumor stage (II vs. I: hazard ratio (HR), 3.781; 95% confidence index (CI), 2.844-5.025; P < 0.001; III vs. I: HR, 7.476; 95% CI, 5.481-10.20; P < 0.001) and G-Ki67 (II vs. I: HR, 1.299; 95% CI, 1.038-1.624; P = 0.022; III vs. I: HR, 1.942; 95% CI, 1.477-2.554; P < 0.001) were independent prognostic factors in the developing cohort. The result was rectified in the validation cohort. In subgroups analysis, G-Ki67 (II vs. I: HR, 1.866 ; 95% CI, 1.045-3.334; P = 0.035; III vs. I: HR, 2.333 ; 95% CI, 1.156-4.705; P = 0.018) also had a high differentiation for survival prediction.

CONCLUSION:

Our findings indicate that three-categories of G-Ki67 in resectable PDAC according to the routine pathological descriptions provided additional prognostic information complementary to the TNM staging system.

• Authors: Bo Li, Xiaoyi Yin, Xiuwen Ding, Guoxiao Zhang, Hui Jiang, Cuimin Chen, Shiwei Guo, Gang Jin
• Journal: BMC surgery (BMC Surg) Vol. 23 Issue 1 Pg. 370 (Dec 08 2023) ISSN: 1471-2482 [Electronic] England
• PMID: 38066512 (Publication Type: Journal Article)
• Copyright: © 2023. The Author(s).

Chemical References

• Ki-67 Antigen

Topics

• Humans
• Ki-67 Antigen
• Retrospective Studies
• Pancreatic Neoplasms (pathology)
• Carcinoma, Pancreatic Ductal (surgery, pathology)
• Prognosis
• Adenocarcinoma (surgery)