Abstract | Introduction: Aim: This prospective study attempted to ascertain the utility of 18F-FCH PET/CT as an investigation in preoperative localization of abnormal parathyroid tissue in recurrent/persistent primary hyperparathyroidism while comparing it with 99mTc-Sestamibi dual-phase scintigraphy with early single-photon emission CT (SPECT)/CT and neck ultrasonography (USG). Methods: Twenty patients with biochemical features of recurrent/persistent primary hyperparathyroidism were enrolled into this study. They underwent neck USG, 99mTc-Sestamibi dual-phase scintigraphy with early SPECT/CT and 18F-FCH PET/CT for localization of parathyroid lesions. Six patients underwent surgical resection of the detected lesions, 3 were awaiting surgery, and 11 were managed conservatively. One patient died due to COVID. Results: The calculated positive predictive values on a per-lesion basis of neck USG, 99mTc-sestamibi scintigraphy and early SPECT/CT and 18F-FCH PET/CT in the cohort of the 5 operated patients were 75% (3/4), 71.4% (5/7), and 71.4% (5/7), respectively. On a per-patient basis, the lesion detection rate was 100% for 99mTc-sestamibi scan and FCH PET (5/5) and 80% on neck USG (4/5). Conclusion:
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Authors | Ritwik Wakankar, Yamini Dharmashaktu, A Nishikant Damle, Praveen Kumar, Chandrasekhar Bal, Rakesh Kumar, Madhavi Tripathi, Shipra Agarwal, Rajesh Khadgawat, Sunil Chumber, Chitresh Kumar |
Journal | Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
(Indian J Nucl Med)
2023 Jul-Sep
Vol. 38
Issue 3
Pg. 218-223
ISSN: 0972-3919 [Print] India |
PMID | 38046977
(Publication Type: Journal Article)
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Copyright | Copyright: © 2023 Indian Journal of Nuclear Medicine. |