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Differences in Absorption and Metabolism between Structured 1,3-Oleate-2-palmitate Glycerol and 1-Oleate-2-palmitate-3-linoleate Glycerol on C57BL/6J Mice.

Abstract
This study investigated differences in absorption and metabolism between 1,3-oleate-2-palmitate glycerol (OPO) and 1-oleate-2-palmitate-3-linoleate glycerol (OPL) using C57BL/6J mice. OPL was associated with higher postprandial plasma total triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C) concentrations, and the ratio of LDL-C to high-density lipoprotein cholesterol (HDL-C) compared to those of OPO (p > 0.05). OPO significantly increased postprandial oleic acid (OA) concentrations compared to OPL over the entire monitoring period (p < 0.05), while OPL significantly elevated linoleic acid (LA) levels compared to OPO (p < 0.05). After 1 month of feeding, the mice in both OPO and OPL groups showed lower final weight, weight gain, and liver TG, LDL-C, and LDL/HDL concentrations compared to the control (soybean oil) group. Lipidomics results showed that OPO increased the biosynthesis of very long-chain fatty acids and decreased the abundance of AcCa (16:1), AcCa (18:2), AcCa (18:1), AcCa (16:0), CarE (16:0), and CarE (16:1) relative to OPL. These lipid metabolites were positively correlated with liver TG, LDL-C, and LDL/HDL levels and negatively related to peroxisome proliferator-activated receptors α (PPARα) and acyl-CoA oxidase (ACOX1) expression. This study showed differences in physiologic functions between OPO and OPL and provided support for the future application of OPL in infant formula.
AuthorsTeng Wei, Dengfeng Tan, Shengyue Zhong, Hong Zhang, Zeyuan Deng, Jing Li
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 71 Issue 49 Pg. 19610-19621 (Dec 13 2023) ISSN: 1520-5118 [Electronic] United States
PMID38038963 (Publication Type: Journal Article)
Chemical References
  • Oleic Acid
  • Linoleic Acid
  • Palmitates
  • Glycerol
  • Cholesterol, LDL
  • Triglycerides
  • Linoleic Acids
Topics
  • Humans
  • Mice
  • Animals
  • Oleic Acid (metabolism)
  • Linoleic Acid (metabolism)
  • Palmitates
  • Glycerol
  • Cholesterol, LDL
  • Mice, Inbred C57BL
  • Triglycerides (metabolism)
  • Linoleic Acids

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