Cyclin-dependent kinase inhibitors are approved in combination with hormonal
therapy for treatment of
hormone receptor expressing breast
cancers. Activity in
hormone receptor expressing gynecologic
cancers has been postulated.
Granulosa cell tumor of the ovary is one such
cancer, which is relatively resistant to traditional cytotoxic
chemotherapy. We report a case series of 7 heavily pre-treated patients with recurrent
granulosa cell tumor of the ovary with a
cyclin-dependent kinase inhibitor in combination with hormonal
therapy, with 3 patients demonstrating partial response and 2 with stable disease. As of the data cutoff, 3 patients remained on treatment and 5 were alive, with true medians for
duration of treatment and overall survival not reached (medians at data cutoff of 64 weeks and 62 months respectively). The treatment was generally well tolerated, with 1 patient choosing to discontinue treatment due to grade 3
fatigue. This regimen represents a possible option in the treatment of
granulosa cell tumor of the ovary, warranting further prospective study for this unmet need in this indolent disease which often requires many lines of treatment.