Abstract |
A mineral oil essentially used in the jute industry for the "batching" of jute fibers, and earlier reported to be nontumorigenic on mouse skin, has been found to be a tumor promoter following a two-stage mouse-skin bioassay protocol. The types of tumors developed after initiation with a single dose of urethane or 3-methylcholanthrene (subcutaneously), followed by repeated skin painting with jute batching oil (JBO) included benign papillomas, keratoacanthomas, and fibrosarcomas. Chemical analysis of this oil indicated the total aromatic content was 11.71% and the amount of fluoranthene, pyrene, chrysene, and triphenylene was in the range of 192.54 to 227.79 mg/kg in the test sample. The underlying biochemical mechanisms for the tumor-promoting effect of JBO seemed to operate through a different pathway rather than involving the induction of cytochrome-dependent monoxygenase and N-demethylase activities in the tissue.
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Authors | N K Mehrotra, S Kumar, R Agarwal, M Antony |
Journal | Environmental research
(Environ Res)
Vol. 42
Issue 1
Pg. 12-23
(Feb 1987)
ISSN: 0013-9351 [Print] Netherlands |
PMID | 3803329
(Publication Type: Journal Article)
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Chemical References |
- Carcinogens
- jute batching oil
- Mineral Oil
- Aryl Hydrocarbon Hydroxylases
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Topics |
- Animals
- Aryl Hydrocarbon Hydroxylases
(metabolism)
- Carcinogens
(pharmacology)
- Liver
(enzymology)
- Mice
- Mineral Oil
(analysis, pharmacology)
- Skin
(drug effects, enzymology, pathology)
- Skin Neoplasms
(mortality, pathology)
- Time Factors
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