Eosinophilic gastroenteritis (EGE) can occur throughout the gastrointestinal tract, from the stomach to the colon. Typical known symptoms are
abdominal pain,
nausea,
vomiting, and
diarrhea. In addition, lesions in the intestinal mucosa may cause
weight loss,
protein-losing enteropathy (PLE), and other problems. A 6-month-old girl with no previous medical history was brought to our hospital after an afebrile 1-min clonic seizure. Blood tests showed low concentrations of serum
calcium and
albumin. After the correction of
hypocalcemia with
gluconic acid, there was no recurrence of seizure. Technetium-99m scintigraphy showed slight leakage of
protein from the intestinal tract, which led us to conclude that the
hypocalcemia and
hypoalbuminemia were caused by PLE. Gastrointestinal endoscopy and biopsy performed to detect the cause of PLE revealed the presence of EGE. After starting administration of an
amino acid-based formula, gastrointestinal symptoms of
diarrhea or
vomiting did not reappear. The
serum albumin concentration normalized, and her
weight gain improved. We report the first case of EGE in an infant who was diagnosed based on seizure. This case shows that infants with EGE may present with seizure resulting from
hypocalcemia caused by PLE.