Association between triglyceride glucose-body mass index and heart failure in subjects with diabetes mellitus or prediabetes mellitus: a cross-sectional study.

Abstract

Background:

The triglyceride glucose-body mass index (TyG-BMI) is a surrogate indicator of insulin resistance. However, the association of TyG-BMI with heart failure (HF) in individuals with diabetes mellitus or prediabetes mellitus is unknown.

Methods:

This study included 7,472 participants aged 20-80 years old with prediabetes or diabetes from the National Health and Nutrition Examination Survey (2007-2018). The TyG-BMI was calculated as Ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] × BMI, and individuals were categorized into tertiles based on TyG-BMI levels. The relationship of TyG-BMI with HF was analyzed using multiple logistic regression models. Subgroup analyses were stratified by gender, age, hypertension, and diabetes mellitus status.

Results:

This cross-sectional study had 7,472 participants (weighted n = 111,808,357), including 329 HF participants. Participants with a high TyG-BMI were prone to HF. The highest tertile group with a fully adjusted model was more likely to have HF compared to the lowest tertile group (odds ratio [OR], 2.645; 95% CI, 1.529-4.576). Restricted cubic spline analysis showed a significant dose-response relationship between TyG-BMI and HF (P < 0.001). In subgroup analyses, similar results were seen in terms of age (≥50 years old), gender, hypertension, and diabetes mellitus status.

Conclusion:

A high TyG-BMI is significantly associated with HF risk in participants with diabetes mellitus or prediabetes mellitus.

• Authors: Shuping Yang, Xiangxiang Shi, Wanlu Liu, Zhaokai Wang, Ruoshui Li, Xianzhi Xu, Chaofan Wang, Lei Li, Ruili Wang, Tongda Xu
• Journal: Frontiers in endocrinology (Front Endocrinol (Lausanne)) Vol. 14 Pg. 1294909 ( 2023) ISSN: 1664-2392 [Print] Switzerland
• PMID: 38027163 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023 Yang, Shi, Liu, Wang, Li, Xu, Wang, Li, Wang and Xu.

Chemical References

• Glucose
• Triglycerides
• Blood Glucose

Topics

• Humans
• Young Adult
• Adult
• Middle Aged
• Aged
• Aged, 80 and over
• Prediabetic State (complications, epidemiology, diagnosis)
• Glucose
• Body Mass Index
• Cross-Sectional Studies
• Triglycerides
• Diabetes Mellitus, Type 2
• Nutrition Surveys
• Risk Factors
• Blood Glucose (analysis)
• Heart Failure (epidemiology, etiology)
• Hypertension