Recently, the role of inorganic
ions has been explored for its wound-healing applications.
Ions do play key role in the normal functioning of the skin, including the epidermal barrier property, maintaining redox balance, enzymatic activities, tissue remodeling, etc. The care of chronic
wounds is a concern and new cost-effective therapeutic strategies that modulate the
wound microenvironment and cell behaviour are needed. First, this review illustrates the
ions that play a role in wound healing and their molecular mechanisms that are accountable for modifying the
wound. Further, the emerging strategies using
metal ions to modulate the healing will be discussed. In this direction, localized delivery of inorganic
ions of importance using advanced
wound care
biomaterials for wound healing applications is discussed.