Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report.

Abstract

We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by bacteraemic ventilator-associated pneumonia (VAP) caused by multidrug-resistant Acinetobacter baumannii (MDR-AB) isolated on pleural fluid culture, treated with colistin and cefiderocol for about 3 weeks. The molecular research of MDR-AB on transtracheal aspirate was negative following this therapy. The aim is to show the safety, efficacy and tolerability of colistin-based combination therapy with cefiderocol for Acinetobacter baumannii infection in HIV-infected patient.

• Authors: Rosa Anna Passerotto, Francesco Lamanna, Damiano Farinacci, Alex Dusina, Simona Di Giambenedetto, Arturo Ciccullo, Alberto Borghetti
• Journal: Infectious medicine (Infect Med (Beijing)) Vol. 2 Issue 2 Pg. 143-147 (Jun 2023) ISSN: 2772-431X [Electronic] China
• PMID: 38013739 (Publication Type: Case Reports)
• Copyright: © 2023 The Authors.