Clinical features and risk factors of plastic bronchitis caused by Mycoplasma pneumoniae pneumonia in children.

Abstract

BACKGROUND:

We analyzed the clinical characteristics of children with plastic bronchitis (PB) caused by Mycoplasma pneumoniae (MP) and explored its risk factors.

METHODS:

We prospectively analyzed clinical data of children with MP pneumonia (MPP) treated with fiberoptic bronchoscopy (FB). Patients were classified into a PB and non-PB group. General information, clinical manifestations, laboratory tests, results of computed tomography scan, and FB findings were compared between groups. We conducted statistical analysis of risk factors for developing PB.

RESULTS:

Of 1169 children who had MPP and were treated with FB, 133 and 1036 were in the PB and non-PB groups, respectively. There were no significant differences in sex, age, and incident season between groups (P > 0.05). The number of children in the PB group decreased during the COVID-19 pandemic. Compared with children in the non-PB group, those in the PB group had longer duration of hospitalization, increased levels of neutrophil (N), C-reactive protein (CRP), procalcitonin (PCT), D-dimer, lactate dehydrogenase (LDH), alanine transaminase (ALT) and aspartate transaminase (AST); lower levels of lymphocyte (L) and platelet (PLT); and higher incidence of lack of appetite, decreased breath sounds, single lobar infiltrate, pleural effusion, pericardial effusion, mucosal erosion and/or necrosis, and bronchial embolization. L levels and pleural effusion were identified as risk factors in multivariate logistic regression.

CONCLUSIONS:

Children with PB caused by MPP had a strong and local inflammatory response. L levels and pleural effusion were independent risk factors of PB with MPP in children. Our findings will help clinicians identify potential PB in pediatric patients for early and effective intervention.

• Authors: Lei Yang, Yuyan Zhang, Changqing Shen, Zhouhua Lu, Tongshu Hou, Fenghai Niu, Yuzhong Wang, Jun Ning, Ruihan Liu
• Journal: BMC pulmonary medicine (BMC Pulm Med) Vol. 23 Issue 1 Pg. 468 (Nov 23 2023) ISSN: 1471-2466 [Electronic] England
• PMID: 37996853 (Publication Type: Journal Article)
• Copyright: © 2023. The Author(s).

Topics

• Child
• Humans
• Mycoplasma pneumoniae
• Pandemics
• Retrospective Studies
• Pneumonia, Mycoplasma (complications, epidemiology, drug therapy)
• Pleural Effusion
• Risk Factors
• Bronchitis (epidemiology)