Zingiberis rhizoma-based carbon dots alter serum oestradiol and follicle-stimulating hormone levels in female mice.

Abstract

Chinese herbs contain substances that regulate female hormones. Our study confirmed that Zingiberis rhizoma carbonisata contains Zingiberis rhizoma-based carbon dots (ZR-CDs), which exert regulatory effects on serum oestradiol and FSH in mice and show impacts on endometrial growth and follicular development that potentially affect the ability of female fertility. ZR-CDs were characterized to clarify the microstructure, optical features, and functional group characteristics. It shows that ZR-CDs are spherical carbon nanostructures ranging from 0.97 to 2.3 nm in diameter, with fluorescent properties and a surface rich in functional groups. We further investigated the impact of ZR-CDs on oestradiol and FSH in serum, growth, and the development of ovarian and uterine using normal female mice and exogenous oestradiol intervention model. It was observed that ZR-CDs accelerated oestrogen metabolism and attenuated oestradiol-induced endometrial hyperplasia. Simultaneously, ZR-CDs triggered an increase in FSH, even in the presence of high-serum oestradiol that inhibits FSH secretion. Our findings suggest that ZR-CDs could be a potential therapeutic treatment for anovulatory menstruation.

• Authors: Yumin Chen, Xue Bai, Ying Zhang, Yafang Zhao, Huagen Ma, Yunbo Yang, Meijun Wang, Yinghui Guo, Xiaopeng Li, Tong Wu, Yue Zhang, Hui Kong, Yan Zhao, Huaihua Qu
• Journal: Artificial cells, nanomedicine, and biotechnology (Artif Cells Nanomed Biotechnol) Vol. 52 Issue 1 Pg. 12-22 (Dec 2024) ISSN: 2169-141X [Electronic] England
• PMID: 37994799 (Publication Type: Journal Article)

Chemical References

• Luteinizing Hormone
• Follicle Stimulating Hormone
• ginger extract
• Estradiol

Topics

• Female
• Mice
• Animals
• Luteinizing Hormone
• Follicle Stimulating Hormone (pharmacology, therapeutic use)
• Ovary (metabolism)
• Estradiol (pharmacology)