Abstract |
The authors summarize recent updates in the prevention and management of cytomegalovirus (CMV) in solid organ transplant (SOT) recipients with a focus on CMV seronegative recipients of organs from seropositive donors (CMV D+/R-) who are at highest risk of CMV infection and disease. They discuss advantages of preemptive therapy for CMV disease prevention in CMV D+/R- liver transplant recipients, letermovir for CMV prophylaxis, and updates in the development of monoclonal antibodies and vaccines as immune-based preventative strategies. They review the roles of maribavir and virus-specific T cells for management of resistant or refractory CMV infection in SOT recipients.
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Authors | Kathleen M Doss, Madeleine R Heldman, Ajit P Limaye |
Journal | Infectious disease clinics of North America
(Infect Dis Clin North Am)
(Nov 20 2023)
ISSN: 1557-9824 [Electronic] United States |
PMID | 37989636
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2023 Elsevier Inc. All rights reserved. |