The cocoon
silk of silkworms (Bombyx mori) has multiple potential applications in biomedicine due to its good biocompatibility, mechanical properties, degradability, and plasticity. Numerous studies have confirmed that
silk material dressings are more effective than traditional ones in the skin wound healing process.
Silk material research has recently moved toward functionalized
biomaterials and achieved remarkable results. Herein, we summarize the recent advances in functionalized
silk materials and their efficacy in skin wound healing. In particular, transgenic technology has realized the specific expression of human
growth factors in the
silk glands of the silkworms, which lays the foundation for fabricating novel and low-cost functionalized materials. Without a green and safe preparation process, the best raw
silk materials cannot be made into medically safe products. Therefore, we provide an overview of green and gentle approaches for
silk degumming and
silk sericin (SS) extraction. Moreover, we summarize and discuss the processing methods of
silk fibroin (SF) and SS materials and their potential applications, such as
burns, diabetic
wounds, and other
wounds. This review aims to enhance our understanding of new advances and directions in
silk materials and guide future biomedical research.