Abstract | BACKGROUND: METHODS: Fifty-four stage I-III patients' responses to the Multidimensional Fatigue Inventory (MFI) and to the Functional Assessment of Cancer Therapy-Breast (FACT-B) were analyzed by a linear covariance pattern model. Chemotherapy regimen, age, baseline fatigue level, body-mass-index and cancer stage were added to the model to estimate their impact on both outcomes. RESULTS: All fatigue dimensions worsened in clinically relevant levels. Physical fatigue worsened the most, mental fatigue the least. For quality of life, physical and functional well-being worsened the most. Only emotional well-being improved during chemotherapy. Physical well-being worsened more during standard than during dose-dense chemotherapy, and more during anthracycline than during taxane cycles. Age, body-mass-index and cancer stage had no impact. The higher the fatigue levels at baseline, the less they worsened during chemotherapy. CONCLUSIONS: STUDY REGISTRATION: The study was registered in the German Clinical Trials Register in May 2019 (DRKS00016761).
|
Authors | Florian Pelzer, Wilfried Tröger, Marcus Reif, Susanne Schönberg, David D Martin, Cornelia Müller, Isabell Utz-Billing, Thorsten Kühn, Stephan Baumgartner, Marion Kiechle, Daniela Paepke |
Journal | Breast cancer (Tokyo, Japan)
(Breast Cancer)
Vol. 31
Issue 1
Pg. 124-134
(Jan 2024)
ISSN: 1880-4233 [Electronic] Japan |
PMID | 37966690
(Publication Type: Multicenter Study, Journal Article)
|
Copyright | © 2023. The Author(s). |
Topics |
- Humans
- Female
- Breast Neoplasms
(psychology)
- Quality of Life
- Neoadjuvant Therapy
(adverse effects)
- Prospective Studies
- Chemotherapy, Adjuvant
(adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
|