RNA binding proteins (RBPs) are crucial for cell function, tissue growth, and disease development in disease or normal physiological processes. RNA binding motif
protein 47 (RBM47) has been proven to have anti-
tumor effects on many
cancers, but its effect is not yet clear in
renal cancer. Here, we demonstrated the expression and the prognostic role of RBM47 in public databases and clinical samples of
clear cell renal carcinoma (ccRCC) with bioinformatics analysis. The possible mechanism of RBM47 in
renal cancer was verified by gene function prediction and in vitro experiments. The results showed that RBM47 was downregulated in
renal cancers when compared with control groups. Low RBM47 expression indicated poor prognosis in ccRCC. RBM47 expression in
renal cancer cell lines was reduced significantly when compared to normal renal tubular epithelial cells. Epithelial-mesenchymal transition (EMT) and
transforming growth factor-β signaling pathway was associated with RBM47 in ccRCC by Gene set enrichment analysis. RBM47 expression had a positive correlation with
e-cadherin, but a negative correlation with snail and
vimentin. RBM47 overexpression could repress the migration, invasion activity, and proliferation capacity of
renal cancer cells, while RBM47 inhibition could promote the development of the malignant features through EMT signaling by RNA stability modification. Therefore, our results suggest that RBM47, as a new molecular
biomarker, may play a key role in the
cancer development of ccRCC.