Gut microbiota and immunotherapy of renal cell carcinoma.

Abstract

The gut microbiome has recently been proposed as a key player in cancer development and progression. Several studies have reported that the composition of the gut microbiome plays a role in the response to immune checkpoint inhibitors (ICIs). The gut microbiome modulation has been investigated as a potential therapeutic strategy for cancer, mainly in patients undergoing therapy with ICIs. In particular, modulation through probiotics, FMT or other microbiome-related approaches have proven effective to improve the response to ICIs. In this review, we examine the role of the gut microbiome in enhancing clinical responses to ICIs in the treatment of renal cancer.

• Authors: Stefano Bibbò, Serena Porcari, Livio Enrico Del Vecchio, Andrea Severino, Benjamin H Mullish, Gianluca Ianiro, Antonio Gasbarrini, Giovanni Cammarota
• Journal: Human vaccines & immunotherapeutics (Hum Vaccin Immunother) Vol. 19 Issue 3 Pg. 2268982 (12 15 2023) ISSN: 2164-554X [Electronic] United States
• PMID: 37955340 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)

Chemical References

• Immune Checkpoint Inhibitors

Topics

• Humans
• Carcinoma, Renal Cell (therapy)
• Gastrointestinal Microbiome
• Immunotherapy
• Kidney Neoplasms (therapy)
• Immune Checkpoint Inhibitors (therapeutic use)
• Neoplasms