Abstract | BACKGROUND: METHODS AND RESULTS: 603 newly diagnosed essential hypertensive subjects and 508 healthy subjects were preliminarily screened, 47 healthy subjects and 40 newly diagnosed essential hypertensive subjects without any chronic diseases were recruited. The results showed that the levels of circulating TSP2 were elevated in essential hypertensive subjects. The levels of TSP2 positively associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and other clinical parameters, including homeostasis model assessment of insulin resistance (HOMA-IR), brachial-ankle pulse wave velocity, and serum triglycerides, but negatively associated with nocturnal urine Na+ concentration and excretion and high-density lipoprotein cholesterol. Results of multiple linear regressions showed that HOMA-IR and nocturnal Na+ excretion were independent factors related to circulating TSP2. Mantel-Haenszel chi-square test displayed linear relationships between TSP2 and SBP (χ2 = 35.737) and DBP (χ2 = 26.652). The area under receiver operating characteristic curve (AUROC) of hypertension prediction was 0.901. CONCLUSION: Our study suggests for the first time that the circulating levels of TSP2 may be a novel potential biomarker for essential hypertension. The association between TSP2 and blood pressure may be, at least in part, related to the regulation of renal Na+ excretion, insulin resistance, and/or endothelial function.
|
Authors | Xiaoxin Zhou, Longlong Zhang, Xiaoqian Lin, Xi Chen, Hong Liu, Xiaoli Yuan, Qiuxia Zhao, Weiwei Wang, Xun Lei, Pedro A Jose, Chunyan Deng, Jian Yang |
Journal | Clinical and experimental hypertension (New York, N.Y. : 1993)
(Clin Exp Hypertens)
Vol. 45
Issue 1
Pg. 2276029
(Dec 31 2023)
ISSN: 1525-6006 [Electronic] England |
PMID | 37943619
(Publication Type: Journal Article)
|
Chemical References |
- thrombospondin 2
- Thrombospondins
- Sodium
- Biomarkers
|
Topics |
- Humans
- Insulin Resistance
- Ankle Brachial Index
- Pulse Wave Analysis
- Hypertension
- Thrombospondins
- Sodium
- Blood Pressure
- Essential Hypertension
(complications)
- Biomarkers
|