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Resolvin D1 attenuates Ang II-induced hypertension in mice by inhibiting the proliferation, migration and phenotypic transformation of vascular smooth muscle cells by blocking the RhoA/mitogen-activated protein kinase pathway.

Abstract
The proliferation, migration and phenotypic transformation of vascular smooth muscle cells contribute to vascular remodeling and hypertension. Resolvin D1 (RvD1) is a specialized pro-resolving lipid mediator that has been shown to have anti-inflammatory effects and can protect against different cardiovascular diseases. However, the role and mechanism of RvD1 in hypertension are not clear. The current study investigated the role of RvD1 in Ang II-induced hypertensive mice and Ang II-stimulated rat vascular smooth muscle cells. The results showed that RvD1 treatment significantly attenuated hypertension and vascular remodeling, as indicated by decreases in blood pressure, aortic media thickness and collagen deposition. In addition, RvD1 inhibited the proliferation, migration and phenotypic transformation of vascular smooth muscle cells (VSMCs) in vivo and in vitro . Notably, the protective effects of RvD1 were mediated by the Ras homolog gene family member A (RhoA)/mitogen-activated protein kinase (MAPK) signaling pathway. In conclusion, our findings demonstrated the potential benefits of RvD1 as a promising therapeutic agent in the treatment of vascular remodeling and hypertension.
AuthorsCheng Wei, Jishou Zhang, Shanshan Peng, Jianfang Liu, Yao Xu, Mengmeng Zhao, Shuwan Xu, Wei Pan, Zheng Yin, Zihui Zheng, Juan-Juan Qin, Jun Wan, Menglong Wang
JournalJournal of hypertension (J Hypertens) Vol. 42 Issue 3 Pg. 420-431 (Mar 01 2024) ISSN: 1473-5598 [Electronic] Netherlands
PMID37937508 (Publication Type: Journal Article)
CopyrightCopyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
Chemical References
  • Mitogen-Activated Protein Kinases
  • resolvin D1
  • Angiotensin II
  • Docosahexaenoic Acids
Topics
  • Mice
  • Rats
  • Animals
  • Mitogen-Activated Protein Kinases (metabolism, pharmacology)
  • Muscle, Smooth, Vascular (metabolism)
  • Vascular Remodeling (physiology)
  • Hypertension (chemically induced, drug therapy, metabolism)
  • Cell Proliferation
  • Angiotensin II (pharmacology)
  • Myocytes, Smooth Muscle
  • Cells, Cultured
  • Docosahexaenoic Acids

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