Evaluation and targeting of amyloid precursor protein (APP)/amyloid beta (Aβ) axis in amyloidogenic and non-amyloidogenic pathways: A time outside the tunnel.

Abstract

In Alzheimer disease (AD), amyloid precursor protein (APP) and production of amyloid beta (Aβ) which is generated by amyloidogenic pathway is implicated in neurotoxicity and neuronal cell deaths. However, physiological Aβ level is essential to improves neuronal survival, attenuates neuronal apoptosis and has neuroprotective effect. In addition, physiological APP level has neurotrophic effect on the central nervous system (CNS). APP has a critical role in the brain growth and development via activation of long-term potentiation (LTP) and acceleration of neurite outgrowth. Moreover, APP is cleaved by α secretase to form a neuroprotective soluble APP alpha (sAPPα) in non-amyloidogenic pathway. Consequently, this mini-review purposes to highlight the possible beneficial role of APP and Aβ. In addition, this mini-review discussed the modulation of APP processing and Aβ production.

• Authors: Hayder M Al-Kuraishy, Majid S Jabir, Ali I Al-Gareeb, Ali K Albuhadily, Salim Albukhaty, Ghassan M Sulaiman, Gaber El-Saber Batiha
• Journal: Ageing research reviews (Ageing Res Rev) Vol. 92 Pg. 102119 (Dec 2023) ISSN: 1872-9649 [Electronic] England
• PMID: 37931848 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2023 Elsevier B.V. All rights reserved.

Chemical References

• Amyloid beta-Peptides
• Amyloid beta-Protein Precursor
• Amyloid Precursor Protein Secretases

Topics

• Humans
• Alzheimer Disease (metabolism)
• Amyloid beta-Peptides (metabolism)
• Amyloid beta-Protein Precursor (metabolism)
• Amyloid Precursor Protein Secretases (metabolism)
• Brain (metabolism)