Abstract | IMPORTANCE: African swine fever virus (ASFV) is a highly fatal swine disease that severely affects the pig industry. Although ASFV has been prevalent for more than 100 years, effective vaccines or antiviral strategies are still lacking. In this study, we identified four Bacillus subtilis strains that inhibited ASFV proliferation in vitro. Pigs fed with liquid biologics or powders derived from four B. subtilis strains mixed with pellet feed showed reduced morbidity and mortality when challenged with ASFV. Further analysis showed that the antiviral activity of B. subtilis was based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II. Our findings offer a promising new strategy for the prevention and control of ASFV that may significantly alleviate the economic losses in the pig industry.
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Authors | Changjie Lv, Jingyu Yang, Li Zhao, Zhong Zou, Chao Kang, Qiang Zhang, Chao Wu, Li Yang, Chuxing Cheng, Ya Zhao, Qi Liao, Xiaotong Hu, Chengfei Li, Xiaomei Sun, Meilin Jin |
Journal | Journal of virology
(J Virol)
Vol. 97
Issue 11
Pg. e0071923
(Nov 30 2023)
ISSN: 1098-5514 [Electronic] United States |
PMID | 37929962
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- arctiin
- DNA Topoisomerases, Type II
- Genistein
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Topics |
- Animals
- African Swine Fever
(prevention & control)
- African Swine Fever Virus
- Antiviral Agents
(pharmacology)
- Bacillus subtilis
- DNA Topoisomerases, Type II
(pharmacology)
- Genistein
(pharmacology)
- Swine
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